Collaborators curate pathways or provide support for individual species-specific databases that were created and/or maintained by them. There is data exchange between PlantCyc and the collaborators' databases. There is also coordination of curation to set consistent curation rules and eliminate redundant efforts.

The release notes associated with each new version of PlantCyc list the information from the collaborators' databases that has been entered into PlantCyc. Each additional pathway entered may help to improve the ability of the Pathologic program to predict more pathways as new single species databases are generated using PlantCyc as a reference standard.